Tumors with moderate-to-high uptake on FDG-PET are illustrated in red. Prostate cancer has unpredictable uptake (blue)
18F-FDG = 18F-fluorodeoxyglucose
- Most widely used tracer in oncologic PET
- Only PET tracer approved by US FDA for routine clinical use
- Biologic analogue = Glucose
- Glucose is used in aerobic and anaerobic glycolysis, glucose consumption or metabolism
- Tumor uptake is related to increased and insufficient use of glucose by tumor cells
- Moderate-to-high uptake in most lung, colorectal, esophageal, stomach, head and neck, ovarian and breast cancers
- Variable uptake in thyroid, testicular, hepatocellular, renal, bladder, sarcoma and neuroendocrine tumors
- Unpredictable uptake in prostate cancer
Not tumor specific, uptake can be seen in benign processes that have increased glucose use in cells (inflammatory cells, hyperplastic marrow, thymic cells)
Reference:
Juweid ME and Cheson BD. Positron-emission tomography and assessment of cancer therapy. New Engl J Med 2006;354:496.
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