- Caudal regression syndrome is characterized by absence of segment(s) of the lumbosacral spine
- Unknown etiology but associated with maternal insulin-dependent diabetes
- Associated with multiple congenital anomalies
- On radiography, absence of segment(s) of lumbosacral spine is characteristic. There may be fusion of the iliac bones resulting in small pelvis.
- MR imaging provides information about the position and appearance of conus medullaris, which defines two distinct groups of this disease. In group I the conus ends cephalad to the lower border of L1. In group II the conus terminates below L1 known as tethered cord.
1 . Renshaw T.S. Sacral Agenesis. The Pediatric Spine -Principles and Practice. 1:2214,1994, Raven Press, NewYork
2. Phillips W.A. Sacral Agenesis. Spine - Principles andPractice. 1:2214,1994, Raven Press, New York
3. A.James Barkovich, Congenital Anomalies of the spine.In: Paediatric Neuroimaging ,Vol 2 ,3rd edition, Lippincott Williams & Wilkins,2000 (650-651),
4. Phyllis Glanc et al, The Fetal Musculoskeletal System. In : Carol M. Rumack's Diagnostic Ultrasound;Vol 2, 2nd edition, Mosby. (1224).
5. Beryl R. Benacerraf,Caudal Regression Syndrome and Sirenomelia; in Ultrasound of Fetal Syndromes,edition 1998, (page 250-254); Churchill Livingstone,Philadelphia.
6. Thomas.P.Naidich,Susan I.Blaser,Bradley M.Delman,Congenital Anomalies of Spine and Spinal Cord. In:Scott W. Atlas, Magnetic Resonance Imaging of the Brain and Spine(vol 1) 3rd edition. Philadelphia: Lippincott Williams & Wilkins,2002;( 1589-1593)
7. Renshaw, T. S., 1978. Sacral agenesis: a classification and review of twenty-two cases. Journal of Bone and Joint Surgery, 60A, 373-383.