Figure: Bone scan image shows diffuse increased bone uptake throughout the skeleton with relative absence of kidney uptake (arrows), consistent with "superscan". There are several focal areas of uptake in the ribs, skull (arrowhead), scapulae and extremities indicating metastatic disease in a 73-year-old man with prostate cancer. The patient had a right craniotomy defect seen as a photopenic region on the posterior view.
- Metabolic: homogeneous uptake, usually hot at the calvarium, uptake seen at the extremities
- Metastatic: heterogeneous, usually absent uptake at the calvarium (unless metastatic lesions), uptake at distal extremities usually not seen
- Prostate cancer, breast cancer, lung cancer
- RCC, lymphoma, bladder cancer